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Despite the controversies surrounding Accutane over the past two decades, it remains the only treatment known to effectively "cure" severe cystic acne and prevent acne scarring

10.1038/aps.2016.175 155 ZhuQ.ZhangY.TangJ.TangN.HeY.ChenX.et al (2021)

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Alpha-diversity analyses (Supplementary Figure 3) demonstrated a substantial difference in diversity between the sediment and inoculum used in the simulation experiments (sub-cultured eight times in the Europa fluid medium)