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The beta-coronaviruses cause severe disease and fatalities as compared to other subfamilies of coronaviruses

Intradiscal injection of SB-01 represents a first-in-class approach to treating chronic discogenic back pain

5A-1MQ-treated mice switched from WD to LD (WD/LD-T) showed a rather reduced relative abundance of Akkermansia compared to vehicle-treated DIO animals switched from WD to LD (WD/LD-V), suggesting a unique microbiome mechanism associated with weight loss in the vehicle-treated group switched from WD to LD compared to the 5A-1MQ-treated group that underwent the same diet switch

PMID 32083522

The vast number of individuals affected by this condition, and the approximately 700,000 annual suicide-related deaths, highlight the significant impact it has on public health [33]