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Common assay concentrations range from 100 nM to 10 M, depending on cell type and endpoint

Clinicians estimate vitamin B12 requirements using values such as: Recommended dietary allowance (RDA): RDArefers Trusted Source National Institutes of Health Office of Dietary Supplements Go to sourceto a daily intake that, on average, is enough to meet the nutritional requirements of almost all people without underlying health conditions

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For patients with genuinely adequate B12 status, the addition is unlikely to produce noticeable effects