In mice bred to be deficient in mast cells (kit mutation), fibrosis and a-fib did not develop.[ref] Related article : Atrial fibrillation genes Mast cells are also implicated in the narrowing of the arteries due to atherosclerosis and play a role in stress-induced coronary artery disease
We hypothesized that the topical delivery of liquid NAC via oral rinses may provide localized neuroprotective and mucosal-stabilizing effects, resulting in symptom relief and improved oral health-related quality of life
doi: 10.1128/IAI.00053-13
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Moreover, mitochondrial damage elevates ROS levels (380), which can in turn damage mtDNA and proteins that may be involved in the electron transport chain (ETC), resulting in lowered ATP production and decreased energy levels (381)