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All mechanistic discussions remain observational and exploratory in nature and are strictly limited to non-clinical laboratory research environments

Animal Toxicology Studies Animal toxicology studies tested doses from 0.0027 mg/lb to 9.1 mg/lb via intraperitoneal, intramuscular, intravenous, and oral routes for up to 6 weeks, finding: No acute toxic or lethal dose No gross or histologic toxicity in major organs No hepatotoxicity or nephrotoxicity Negative Ames test (no mutagenicity) Negative chromosomal aberration tests (no genotoxicity) No teratogenicity in rat pregnancy studies No local injection site irritation The LD1 (minimum lethal dose) could not be achieved despite aggressive testing

The injection is meant to be delivered subcutaneously

Not by forcing smooth muscle contraction like standard prokinetics

doi: 10.1093/qjmed/95.10.677 2 CampagnoloN.JohnstonS.CollatzA.StainesD.Marshall-GradisnikS