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doi: 10.1038/s41467-021-27658-x 67 CarlinoMSLarkinJLongGV

3.2.1 Semaglutide ConcentrationTime Profiles Without inclusion of trial factors, the model was able to accurately fit concentration levels across each of the 10-day trials, and thereby demonstrated consistency in PK for the six clinical pharmacology trials used for model development

used FeNTA (ferric nitrilotriacetate complex) to stimulate hepatocytes and observed the proliferation of HSC and the accumulation of type I collagen (Svegliati Baroni et al., 1998)

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suitable for weekly dosing Safety Profile: Well tolerated