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A recent study further demonstrated that circadian regulation of mitochondrial function governs time-of-day-dependent activation of the NLRP3 inflammasome in macrophages, with peak inflammatory responses occurring when mitochondrial membrane potential is highest 135

The substance has been tested for topical use in cosmetics, but injection trials have been limited to rats, mice, dogs, in vitro cells, and lungs removed from transplant patients

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AEON has less than half as much NMN and NR, less than one-fifth the TMG, and only two-thirds of the spermidine

10.3390/cells11142220 23 NieberlerM.ReuningU.ReichartF.NotniJ.WesterH.-J.SchwaigerM.et al (2017)