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Originally identified in human plasma, GHK readily binds copper (II) ions to form the biologically active GHK-Cu complex, which has been extensively studied across regenerative biology, including skin physiology, connective tissue maintenance, wound healing and healthy ageing

Similar to Glutamine, Acetyl-L-Carnitine is specifically used as a medical treatment, mainly for cardiac conditions

Kimji's role is to ensure that the medical claims in this guide are consistent with the published evidence and standard-of-care dermatology practice

additionally, a rat model of ligature-induced periodontitis was shown to induce systemic inflammation and microglial activation, with inflammatory factors, IL-1, IL-6, IL-8, and IL-21, elevated in the peripheral blood and brain (Hu et al., 2021)

The combined anti-inflammatory and antioxidant effects converge to achieve chondroprotection (Figure 2)