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To ensure early diagnosis and intervention, international recommendations recommend that all patients with T1D undergo baseline and repeated thyroid function testing (TSH, free T4) and anti-TPO screening (Frommer And Kahaly 2021)

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As per Madalina Ionescu et al., The marked enhancement of trough GH levels by continuous GHRH stimulation implicates the importance of this effect on increasing IGF-I

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The canonical pyroptosis pathway is initiated by the activation of the NLRP3 inflammasome complex, which includes NLRP3, the adaptor protein ASC containing the CARD domain, and pro-caspase-1 [65]