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Paradoxical findings have more frequently been observed when NOS manipulations are delivered during the induction of opioid tolerance

Increased ATP/ADP ratio induces the closure of ATP-sensitive potassium (K ATP ) channels, leading to membrane depolarization followed by activation of voltage-gated Ca 2+ channels (VGCC) and Ca 2+ influx

Takada and Bannai, 1984)

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Moreover, BPC 157 therapy generated from its distinctive healing effects in various tissues also functions as an eye drops therapy that heals perforating corneal ulcers in rats and rapidly regains corneal transparency (Figures 14, 15) (Masnec et al., 2015)