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It inhibits NNMT (nicotinamide N-methyltransferase), an enzyme regulating metabolism, fat storage, and NAD+ consumption.[4][27][6] NNMT methylates nicotinamide, a NAD+ breakdown product, diverting it from recycling and reducing available NAD+

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Lipogenesis Inhibition In addition to stimulating fat breakdown, AOD9604 inhibits lipogenesis - the synthesis of new fatty acids and triglycerides from glucose and other precursors

AOD-9604 primarily targets fat loss by stimulating lipolysis (fat breakdown) and inhibiting lipogenesis (fat storage)

These studies help characterize the in vivo consequences of NNMT inhibition and inform further mechanistic research