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Additionally, vitamin B12 deficiency can cause neurocognitive manifestations including depression, episodes of psychosis, delirium, dementia, poor memory performance, and cognitive impairment ( In 1978, Carney and Sheffield found that 31% of patients suffering from depression had low serum vitamin B12 levels (65)

Gut Microbiome and Inflammation: In the gut, Berberine modulates the microbial community and reduces permeability, thereby lessening the systemic inflammation often linked to metabolic disorders

Common causes include: injecting air into the vial during mixing, shaking instead of gently swirling, or using non-sterile bacteriostatic water