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This research was financially supported by National Natural Science Foundation of China (81874255), Science and Technology Department of Sichuan Province (2021YJ0194, 2023JDRC0019, 2022ZYD0091) and Health Commission of Sichuan Province (21ZD008, 2023-802), Cadres Health Scientific Project of Sichuan Province (2021-803) and Sichuan Cancer Hospital Research Program (YB2023015, YBR2019003, YB2021023)