CHAC1/MGC4504 is a novel proapoptotic component of the unfolded protein response, downstream of the ATF4-ATF3-CHOP cascade
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341 PGC-1 expression elicits an obvious decrement in the migratory capacity of PC3 and DU145 cells and a robust anti-invasive phenotype, but ERR deletion abolishes the induction of target genes of the transcription factor upon induction of PGC-1
Gene centric pathways correlation analyses showed that the glutathione metabolism pathway ( p = 0.001) was highly ranked, as well as its linked taurine and hypotaurine metabolism pathway ( p = 0.009) (Figure 3B and see Supplementary Tables S8)
The electron donation can affect the receiving molecule in varying ways including neutralizing reactive oxygen species, or maintaining cysteine in proteins in their reduced forms
