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444 Mutations in HSP genes can further contribute to immune dysregulation

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According to Malazy et al

TCA Cycle Enzyme Defects Associated with Cancer At least three of the genes that encode TCA cycle enzymes (or homologues of TCA cycle enzymes), or protein subunits of enzyme complexes, have been shown to manifest mutations in certain types of familial cancer syndromes

These encompass endogenous enzymes, including superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx), and exogenous compounds acquired from the diet, including vitamins C and E, carotenoids, and polyphenols