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Representative experimental areas include: Metabolic disease and obesity: Murine models show that MOTS-C improves insulin sensitivity, enhances skeletal muscle glucose uptake, promotes lipid utilization, and reduces dietinduced obesity while improving glucose tolerance

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Subsequently, a 2026 review in the Journal of the American Academy of Orthopaedic Surgeons classified AOD-9604 as a therapeutic peptide for muscle and cartilage repair, noting that it promotes fat metabolism and may support cartilage repair without markedly altering glucose homeostasis or systemic IGF-1 levels

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