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Obesogenic diet-induced gut barrier dysfunction and pathobiont expansion aggravate experimental colitis

Daniel Uba, MD Published Mar 9, 2026 10 min read Weight loss conversations often revolve around calories, exercise routines, and hormones such as insulin or GLP-1

The benefits are felt almost immediately and typically last 57 days

Its discovery by Sikiri and colleagues opened up a long line of preclinical research into cytoprotection and tissue healing

Furthermore, our patients often respond positively to 600 mg/day of N-acetylcysteine (NAC), which can decrease elevated levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) enzymes by reducing oxidative stress (Sukumaran et al., 2023)