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Notably, although CR does not increase mitochondrial content, the adaptive induction of PGC-1 by CR maintains a functionally efficient electron transport system and mitochondria in skeletal muscle, reflecting the importance of PGC-1 for the ability of dietary restriction to counteract the age-related decrement in mitochondrial respiration

Understanding neuromuscular disorders in chronic fatigue syndrome.8:F1000 Faculty Rev-2020

It's equally crucial to note the potential risks associated with a lack of stringent regulatory oversight in some clinics, which may impact the safety and quality of the procedures

Pettit, F