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A Randomized controlled clinical trial in healthy older adults to determine efficacy of glycine and N-acetylcysteine supplementation on glutathione redox status and oxidative damage
Similarly, in the context of infectious diseases, EV-based vaccines engineered to deliver viral antigens or mRNA cargos have demonstrated strong humoral and cellular immunity against pathogens such as influenza virus, HIV, and SARS-CoV-2, with additional advantages including improved mucosal immunity, reduced reactogenicity, and enhanced stability relative to conventional lipid nanoparticlebased systems [401]
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Still, our data raise the possibility of several additional nodes of regulation of the CIA in response to cysteine limitation that are worthy of further exploration, including inhibition of cytosolic cluster synthesis due to cysteine insufficiency, restriction of mitochondrial cluster export, or differential cluster integration into recipient proteins through the regulation of the chaperone-based trafficking system 79
