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Results: Among 36,801 participants, NVC exhibited a significant midday dip between 11 a.m

However, VacA disrupts the integrity of the gastric epithelial barrier by forming channels or pores in the cell membrane, leading to increased permeability, and plays a role in regulating host cell apoptosis according to cell type and environmental conditions (Reyes, 2023

Whether they reflect dose-related issues, sourcing variability, or true pharmacological effects is unknown, precisely because the human data does not exist to answer that question