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In an in vitro model of Erastin-induced ferroptosis in PC12 neuronal cells, the iron inhibitor curcuminpolydopamine nanoparticles (Cur-PDA NPs) markedly enhanced the chelation of Fe 3+ and Fe 2+ , upregulated superoxide dismutase (SOD) and GSH expression, reduced Fe 2+ and ROS levels, inhibited lipid peroxidation, restored mitochondrial function, and attenuated neuronal ferroptosis

EGCG has been documented to inhibit oxidative stress and neuroinflammation in AD (Liao et al

For Parkinsons disease, the study utilized a unilateral 6-OHDA lesioned rat model

Such comprehensive investigations will provide a more nuanced understanding of vaccination techniques and contribute to enhanced clinical guidelines across a broader spectrum of individuals

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