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A systematic review in 2024 identified 36 studies (35 preclinical, 1 clinical) from 1993 to 2024

From nature to nanomedicine: Enhancing the antitumour efficacy of rhein, curcumin, and resveratrol

ROS-induced mitochondrial dysfunction and DNA damage, along with the inhibition of key redox transcription factors such as Nuclear Factor Erythroid 2-Related Factor 2 (NRF2) may contribute to the persistence of symptoms in both ME/CFS and Long COVID (Jarrott et al., 2022)

Resistance training stimulates anabolic pathways and increases IGF-1 activity

It also supports enzymes such as lysyl oxidase, which crosslink collagen fibers and help build a stronger, more stable extracellular matrix [8]