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Estrogen may play an antidepressant role via the 5-HT system

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It is caused by a trinucleotide expansion within the Fmr1 gene on the X chromosome, resulting in an absence of FMR1 protein 1 (FMRP1) (Verkerk et al., 1991)

Nicotinamide (a form of vitamin B3), also known as niacinamide, is needed for numerous metabolic reactions in the body and has been used historically to treat rosacea

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