prescription meds and some OTC meds (Tylenol) UV radiation, medical X-rays, chemotherapy, electromagnetic fields Alcohol use and abuse Unrelieved stress, poor sleep, and lack of exercise or too strenuous exercise which can produce too many free radicals Poor diet, especially one thats low in vitamins, minerals or antioxidants The natural aging process, which drops cellular glutathione production on average 10% per decade In short, when your body's demand for glutathione outpaces its supply, oxidative stress ramps up and that's when problems start
Brain endothelial tight junction proteins include occludin, claudins (claudin-1, 3, 5, 12), and the membrane-associated guanylate kinase (MAGUK) protein family of zonula occludens (ZO1, ZO2, and ZO3) (Fig
S.StockerR.ChengD.et al (2015)
Alcohol induced sleep is lighter, more fragmentary, and far less restorative 13
These can include mild gastrointestinal upset or allergic reactions