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We synthesize cross-system disease evidencebrain (hypoxia/ischemia, neuroinflammation), heart (divergent roles in acute ischemiareperfusion versus chronic failure), kidney (mitochondrial dysfunction and cGASSTING(cyclic GMPAMP synthasestimulator of interferon genes)driven fibrosis), gastrointestinal tract (stage-specific effects in colorectal cancer and impaired detoxification in ulcerative colitis), bone/metabolic disorders, and the male reproductive systemhighlighting SQORs bidirectional pathology when hydrogen sulfide is excessive or depleted

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Lactoferrin is broadly active against yeasts and highly synergistic with amphotericin B

suggested a synergistic therapeutic effect of polyinosinic-polycytidylic acid combined with 13- cis -retinoic acid in neuroblastoma (82)