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10.1080/15384101.2015.1136038 29 RenX.BjoernstedtM.ShenB.EricsonM

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doi:10.1016/s1357-2725(00)00087-x Compliance Statement This product is intended for laboratory research use only and is not approved for human or veterinary use.

4-HNE represents a highly reactive lipid peroxidation byproduct that induces cellular damage by interacting with proteins, DNA, and other cellular components through iron- and oxygen-mediated chain-breaking reactions ( The transient receptor potential channel TRPM4 has been shown to promote ox-LDL-induced dysfunction in HCAECs through ferroptosis mechanisms ( Additionally, reduced sterol regulatory element-binding protein 1 (SREBP-1) expressiona key transcription factor in lipid and cholesterol metabolismis associated with stable CAD development