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Thus, in deploying APAP as a therapeutic option, one must account for both age-dependent differences in the PK/PD of APAP and the inter-patient variability within the pediatric population itself

Even though our data show that both agents separately caused cell damage, ethanol potentiated the mucosal injury caused by TNBS, an event that was accompanied by a significant depletion of mucosal GSH levels, suggesting that GSH limitation contributed to enhanced cell injury (Table 1)

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