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film has taken in nearly $1 billion worldwide to date, setting a record for the highest-grossing R-rated movie of all time, and Phoenixs turn as the troubled would-be-comedian-turned-murderous-evildoer Arthur Fleck has put landed him at the heart of this years lead actor Oscar race

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Studies have reported acute changes in airway epithelial permeability due to oxidative stress and inflammation, and junction proteins gradually decomposed after long-term CS exposure, leading to the structural destruction of airway epithelial barrier [10,11,12]

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