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It provides broader context for Dihexa's mechanism of action and its position within the angiotensin IV receptor research field, evaluating both the strength and limitations of the existing preclinical evidence base

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Continuous, uninterrupted use beyond 8 weeks has not been characterized in any published model

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To determine the expression of translocated Nrf2 and NF-B in the nucleus, and the levels of Nrf2, Keap1, heme oxygenase-1 (HO-1) and p-IB in the cytoplasm, nuclear and cytoplasmic extracts from the lung tissue were prepared with a previously described method (Rajendrasozhan et al., 2010)