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Small research studies and anecdotal clinical reports suggest that some people tolerate DSIP without major side effects, but standardized long-term safety studies do not exist

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J Vet Med Sci 2016;78:957-62.ArticlePubMedPMC 73

This research shows us that they might be useful to manage food preoccupation and binge eating, but not in their current form. Although this study only featured the data from one person taking tirzepatide, it provides compelling data about how GLP-1 and GIP inhibitors alter electrical signals in the brain, said co-first author Wonkyung Choi, a PhD candidate in Halperns lab