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10.1016/j.parkreldis.2025.107777 120 ZhangL

One drug isnt better than the other, but semaglutide (the active ingredient in Wegovy and Ozempic) targets a single potent pathway (the GLP-1 receptor), while retatrutide is a triple-agonist, acting on GLP-1, GIP, and glucagon receptors

This is sufficient for multi-dose vial use because the preservative continuously suppresses any small microbial load introduced during punctures, preventing it from reaching levels that pose contamination risk

Once the glue is placed, it goes through a process of hardening (sclerosis) shutting the vein from farther use, after which the glue is absorbed by the body

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