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Concurrently, MPs inhibit the nuclear factor erythroid 2-related factor 2/heme oxygenase-1(Nrf2/HO-1) antioxidant system, promoting NF-B nuclear translocation and pro-inflammatory cytokine release (IL-1, IL-6), thereby exacerbating the testicular inflammatory microenvironment and reducing viable sperm counts (88)

Kidney damage concerns usually stem from misuse or unregulated administration not responsible oral supplementation

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2010;298:C38C45

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