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This inhibition reduces intracellular 1-methylnicotinamide (1-MNA) production (EC50 = 2.3 M) and preserves nicotinamide availability for the NAD+ salvage pathway

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Over the past decade, GLP-1 agonists like semaglutide (Ozempic, Wegovy) have dominated the conversation but they arent the only peptides showing promise

While the heart-specific targets of MOTS-c are still being investigated, these findings open the door to the peptides potential use in supporting cardiovascular health

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