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These gut-derived hormones are released in response to food intake, and have the following effects: Promoting insulin release (insulin lowers blood sugar) Blocking glucagon release (glucagon raises blood sugar) Delaying gastric emptying to prevent post-meal highs Promoting a feeling of fullness so you eat less at any given meal Previously approved incretin-based therapies mimic only the GLP-1 hormone

Tissue regulatory T cells: regulatory chameleons

Withdraw the needle and apply pressure to the injection site using gauze, a cotton ball, or a bandage

Tirzepatide once weekly for the treatment of obesity (SURMOUNT-1)

All data used to generate the graphs are provided as source data