Given the importance of glucose and glutamine metabolism in pancreatic cancer cells, it is not surprising that gemcitabine resistance is closely associated with metabolic status, including cellular glucose and glutamine levels
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Even more striking, among "late responders" who had not achieved 5% loss by week 12, a full 90% still reached that threshold by week 72
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Seven of the 22 peptides associated with the frail vs control diagnostic contrast and cognitive decline were cytoskeleton-related, including proteoforms of MAP2, VIM, TUBB, DBN1, TUBA8, PALM and NEFM (Fig