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While oral bioavailability is lower than subcutaneous administration, these studies established that even high oral doses maintained excellent safety profiles, though higher doses (54 mg) were associated with increased gastrointestinal discomfort

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The safety profile of stacked peptide therapy is not well established

Limited electrophysiologic measurements made during some of these interventions resulted in the belief that stimulation of the cerebellum has inhibitory effects on thalamic areas that receive cerebellar inputs, and on motor cortical areas [67, 297,298,299, 301, 302]

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