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A 2021 study in Gut found that long COVID patients had significantly reduced microbiome diversity and specific depletions in beneficial species, including Faecalibacterium prausnitzii and Bifidobacterium bacteria known for their anti-inflammatory and immune-regulatory properties

While leukocytes are essential for immune defense, their activation in the reproductive environment can lead to excessive production of ROS, which in turn can damage spermatozoa

In another study, alogliptin intervention for 3 months improved vasodilation in obesity-induced autophagy in C57BL/6 mice

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329,330 In degenerative joint diseases like OA, the metabolic balance of chondrocytes is disrupted, leading to the overproduction of degrading enzymes and inflammatory mediators, including iNOS, MMP-13, and ADAMTS5 (a disintegrin and metalloproteinase with thrombospondin motifs 5), which participate in cartilage degradation and inflammatory processes