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By improving the ability of muscle and liver cells to oxidize lipids, advanced formulations contribute to reductions in plasma triglycerides, enhanced insulin sensitivity, and decreased fat accumulation

Antioxid Redox Signal 8:81322 Pedrajas JR, Kosmidou E, Miranda-Vizuete A, Gustafsson JA, Wright AP, Spyrou G (1999) Identification and functional characterization of a novel mitochondrial thioredoxin system in Saccharomyces cerevisiae

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In this study, three compounds stood out positively, with IC 50 values ranging from 0.13 to 0.15 M ( 17 19 ), while topiroxostat and allopurinol had IC 50 of 0.02 and 8.80 M, respectively (Figure 9)