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doi: 10.1016/j.autrev.2020.102649 36 McLeodDSACooperDS

In both pathways, cysteine-dependent proteases known as caspases execute apoptotic cell death by cleaving key structural and regulatory proteins, primarily through the action of caspase-3 (CASP3) and caspase-7 (CASP7), with caspase-6 (CASP6) contributing to downstream substrate cleavage and apoptotic progression

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Though many of these strategies remain experimental, their convergence with real-world data, digital phenotyping, and precision medicine frameworks heralds a transformative decade ahead