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Research by the US National Institute of Standards and Technology led to a standardized test method to determine cigarette ignition propensity, and eventually regulations enforcing Reduced Ignition Propensity (RIP) cigarettes have been passed in all US states and other countries

Regionally, this marker is in the American South, specifically in the Upper South, in Appalachia, and specifically in Northern Appalachia

Tobacco smokers are twice as likely as non-smokers to suffer from dry eye syndrome, which manifests as a dehydrated red and itchy eye surface that can lead to impaired vision, infections or corneal ulcers

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