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For instance, Chinese formula Xiaoyaosan alleviates depression-like behaviors by modulating PEBP1-GPX4-mediated ferroptosis in the hippocampus of CUMS mice, implying that ferroptosis could become a novel target for development and research of antidepressant drugs

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To support precise administration in experimental settings, researchers have developed a nasal spray formulation designed for accurate and consistent delivery in preclinical models

This synergy between oxidative stress and neuroinflammation is critical in understanding the molecular mechanisms underlying ethanol-induced depression