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Younger men typically experience faster replenishment rates

Copper itself is a signaling-relevant ion, and several transcription factors and chromatin-associated processes are sensitive to metal availability and redox state

However, the foundational mechanism paper (Benoist et al., 2014 in J Pharmacol Exp Ther) establishing Dihexas HGF/c-Met pathway activation was formally retracted in April 2025 after being flagged since 2021

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To help bridge this gap, risk stratification tools have been developed on the basis of clinical parameters (eg, male sex, cigarette smoking, older age, and length of BE segment)