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Notably, in macrophages, this pathway is triggered during renal fibrogenesis by double-stranded DNA emanating from injured renal tubular epithelial cells (RTECs), thereby instigating a robust inflammatory cascade (Fumika et al., 2023)

doi: 10.1016/s0140-6736(14)60802-3 143 RubioJEScanzelloCFelsonDTAuMBGogginsJPlunkettAet al

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