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All evidence is preclinical

Results: In the derivation cohorts, the model achieved high prediction performance (dicho/tricho AUCs: 0.75-0.88/0.68-0.84) and good robustness

Regulates growth hormone (GH) receptors

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This enzymatic reaction consumes both nicotinamide and SAM, leading to depletion of NAD+ storesa critical coenzyme required for cellular energy production, DNA repair, and metabolic regulation