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Furthermore, fallopian tube epithelial cells are constantly exposed to potentially toxic constituents [e.g., labile iron and reactive oxygen species (ROS)] derived from retrograde menstrual reflux even before the accumulation of somatic or oncogenic mutations [5]

Cancer Prev Res 5(2):179188 Fraga MF, Ballestar E, Villar-Garea A, Boix-Chornet M, Espada J, Schotta G, Bonaldi T, Haydon C, Ropero S, Petrie K, Iyer NG, Prez-Rosado A, Calvo E et al (2005) Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer

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