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Mechanistically, metformin specifically inhibits mitochondrial respiratory chain complex 1 in a range of tissues, leading to the activation of AMP-activated protein kinase (AMPK) in various tissues, including hepatocytes, muscles, and neurons (Top et al., 2022)

17 18 In addition, cell studies indicate Alzheimers disease may be linked with lower DNA methylation, 19 and mitochondrial dysfunction is widely considered an important driver in Alzheimers disease development

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Vitamin C is well-known for its ability to lighten skin and reduce dark spots, acne scars, and uneven pigmentation