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The mechanism relies on two anatomical pathways: The Olfactory Pathway: The olfactory epithelium sits at the top of the nasal cavity, directly beneath the olfactory bulb of the brain

The landmark studies that established Dihexa's cognitive enhancement properties used daily dosing to demonstrate proof-of-concept, not because frequency optimization studies determined daily was superior

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Research: Gimble JM, Ptitsyn AA, Goh BC, Hebert T, Yu G, Wu X, Zvonic S, Shi X-M and Floyd ZE (2009)

The optimal retatrutide dose in any research context depends on the balance between efficacy and tolerability