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J Invest Dermatol (1991) 97:70112

At the other end of the spectrum (known as hardmaxxing), they "bone-smash" or have jaw surgery to "ascend" and reach a Neanderthal-like appearance

Microglia and astrocytes in the CNS are activated to release inflammatory factors and damage neurons, and in the peripheral immune system, alterations in blood immune cell subsets and function, and elevated inflammatory factors correlate with central inflammatory and neurodegenerative changes, but the consistency is influenced by clinical phenotype and disease stage [160, 161]

NLRP3 Inflammasome at the Interface of inflammation, endothelial dysfunction, and type 2 diabetes

Donahue JE, Flaherty SL, Johanson CE, et al