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In particular, the activation of mitogen-activated protein kinase (MAPk) pathway (especially of extracellular-signal-regulated kinase (ERK) and p38) and the inhibition of Mammalian target of rapamycin (mTOR) activity promote autophagy

That matters because glucagon activation increases your baseline calorie burn and enhances fat breakdown through heat production, basically adding a metabolic accelerator that semaglutide and tirzepatide lack entirely

Two key findings reinforce this conclusion

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234 MTAP is located in the periphery of the tumor suppressor cyclin-dependent kinase inhibitor 2 A (CDNK2A), and the co-deletion of the two genes occurs in ~15% of cancers and results in a highly aggressive tumor with a poor prognosis