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Importantly, the cytokine transduces a pro-inflammatory signal from the periphery to the CNS through endothelial cells of the bloodbrain barrier [75, 76]

Starting low and escalating gradually produced fewer gastrointestinal side effects than starting directly at a higher dose, which is why the 2mg +2mg-every-4-weeks schedule became the standard escalation approach in the published data

The effects persisted even during the last placebo night after treatment, or administration of DSIP

After your Injection: Grab your alcohol pad, place it on the injection site and using your 2 fingers apply gentle pressure in a circular motion